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1994-10-25
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Document 3200
DOCN M94A3200
TI A trial to establish a novel mouse model for AIDS.
DT 9412
AU Yoshimoto T; Nagase H; Kojima K; Kanamori Y; Nariuchi H; Department of
Allergology, Institute of Medical Science,; University of Tokyo, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):130 (abstract no. PA0141). Unique
Identifier : AIDSLINE ICA10/94369375
AB OBJECTIVE: To try to establish a novel mouse model for AIDS, we analyzed
various immunological parameters of DDD/1 mice subcutaneously injected
with a mouse mammary tumor virus, MMTV (FM), which we have recently
isolated and has strong superantigenic activity reacting to V beta 8.2+
T cells. METHODS: After subcutaneous injection of MMTV (FM) into four
footpads of DDD/1 mice, draining lymph nodes and spleen were analyzed at
a given time for their cell number, composition of subsets and mitogenic
response against anti-CD3 antibody. Histological analysis of these
tissues was also performed. RESULTS: The draining lymph nodes gradually
became enlarged approximately 10-30 times in size and the percentage of
V beta 8.2+ T cells reached to around 50% in CD4+ T cells by 3 week
after the injection. Spleen also became enlarged approximately 5-folds
bigger than control by 6 weeks after the injection. The mitogenic
response of spleen obtained from mouse injected with MMTV (FM) was
significantly reduced compared to that of control. DISCUSSION AND
CONCLUSIONS: The subcutaneous injection of MMTV (FM) into footpads of
DDD/1 mice was revealed to induce lymphoadenopathy, splenomegaly and
depressed immune response. Although further studies are currently in
progress, these results suggest that DDD/1 mice injected with MMTV (FM)
have a potential to be used as a novel mouse model for AIDS.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY Animal
Comparative Study Disease Models, Animal Lymph
Nodes/IMMUNOLOGY/PATHOLOGY Lymphocyte Subsets/IMMUNOLOGY Lymphocyte
Transformation Mammary Tumor Viruses, Mouse/*PATHOGENICITY Mice Mice,
Inbred Strains Reference Values Spleen/IMMUNOLOGY/PATHOLOGY
Splenomegaly MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).